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The X-Files was inspired by earlier television series which featured elements of suspense and speculative fiction, including Alfred Hitchcock Presents, The Twilight Zone, Night Gallery, Tales from the Darkside, and especially Kolchak: The Night Stalker.
When creating the main characters, Carter sought to reverse gender stereotypes by making Mulder a believer and Scully a skeptic.
Mulder and Scully's boss, Assistant Director Walter Skinner (Mitch Pileggi), also became a main character.
Doggett replaces him as Scully's partner and helps her search for him, later involving Reyes, of whom Doggett had professional knowledge.
The X-Files ends when Mulder is secretly subjected to a military tribunal for breaking into a Top Secret military facility and viewing plans for alien invasion and colonization of Earth.
Over the course of the series, she becomes increasingly dissatisfied with her own ability to approach the cases scientifically.
Mulder and Scully are joined by John Doggett (Robert Patrick) and Monica Reyes (Annabeth Gish) late in the series, after Mulder is abducted.